郑善清

出生年月：1983 年4 月，性别：男，民族：汉 Email:nihaoshanqing@163.com

本人近5 年在国际著名期刊Development、Journal of Biological Chemistry、

Journals of Gerontology, Series A、Age 等上发表论文9 篇，总被引120 多次。并担任

Experimental Gerontology、Food & Function、Bentham Science Publishers （Current

Aging Science ）、International e-Journal of Gerontology and Geriatrics、The Scientific

Pages of Gene and Genome Research、Annals of Clinical and Experimental

Hypertension 等杂志特约审稿人。

教育经历：

2010-2013 博士学位: 药物化学，中国科学院昆明植物研究所。

2007-2010 硕士学位: 分子遗传学, 海南大学

2003-2007 本科学位: 生物技术，华南热带农业大学

研究及工作经历:

2019 年5 月至今 ，黄河学者，伟德国际BETVLCTOR

2014 年7 月至2019 年4 月， 博士后, 加拿大女王大学（Queen’s University, Canada ）

●线虫模型癌细胞发育机制研究。

●抗衰老、抗癌活性天然产物和药物筛选及作用机制研究。

2013-2014 广东省农业科学院

● 天然产物多酚类物质抗衰老和脂肪代谢研究。

2010-2013 中国科学院昆明植物研究所，博士研究内容

● 使用线虫建立抗衰老活性物质筛选模型。

● 评估线虫药物吸收效率和代谢过程。

● 绿原酸抗衰老活性功能的机制研究

2007-2010 海南大学，硕士研究内容

● Sesuvium portulacastrum L.全长cDNA 基因文库的建立和评估。

● Sesuvium portulacastrum L 的Solexa 转录组分析

●抗盐基因克隆

论文发表:

1. Shanqing Zheng, Zhi Qu, Michael Zanetti, Brandon Lam, Ian Chin-Sang. C.

elegans PTEN and AMPK block neuroblast divisions by inhibiting a BMP-Insulin-

PP2A-MAPK pathway. Development 2018 145: dev166876 doi:

10.1242/dev.166876

2. Shanqing Zheng, Hilton Chiu, Jeffrey Boudreau, Tony Papanicolaou, William

Bendena Ian Chinsang. A functional study of all 40 C. elegans insulin-like

peptides. 2018, Journal of Biological Chemistry. (2018.

10.1074/jbc.RA118.004542)

3. Shanqing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Ai-Jun Ding, Gui-Sheng Wu,

Huai-Rong LUO. Chlorogenic Acid Extends the Lifespan of Caenorhabditis

elegans via Insulin/IGF-1 Signaling Pathway. Journals of Gerontology, Series A,

2017, Vol. 72, No. 4, 464–472

4. Shanqing Zheng and Ian D. Chin-Sang. C. elegans Methods to Study PTEN.

Methods in Molecular Biology. Chapter 17. 2015.

5. Shanqing Zheng, Sentai Liao, Yuxiao Zou, Zhi Qu, Weizhi Shen, Ying Shi.

Mulberry leaf polyphenols delay aging and regulate fat metabolism via the

germline signaling pathway in Caenorhabditis elegans. AGE (2014) 36:9719

6. Shanqing Zheng, Sentai Liao, Yuxiao Zou, Zhi Qu, Fan Liu. ins-7 Gene

Expression Is Partially Regulated by the DAF-16/IIS Signaling Pathway in

Caenorhabditis elegans under Celecoxib Intervention. PLOS ONE, 2014, 9(6)

e100320.

7. Shanqing Zheng, Ai-Jun Ding, Guo-Ping Li, Gui-Sheng Wu, Huai-Rong Luo.

Drug Absorption Efficiency in Caenorhbditis elegans Delivered by Different

Methods. PLOS ONE, 2013, 8(2) e56877.

8. Qin-Li Wan, Shanqing Zheng, Gui-Sheng Wu, Huai-Rong Luo. Aspirin extends

the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary

restriction pathway. Experimental Gerontology, 2013(48):499-506.

9. Ai-Jun Ding, Shanqing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Gui-Sheng Wu,

Hua-Ying Sun, Shu-Hua Qi, and Huai-Rong Luo. Current Perspective in the

Discovery of Anti-aging Agents from Natural Products. Nat Prod Bioprospect,

2017 Oct; 7(5): 335–404.

10.Shanqing Zheng, Duan Ruijun, Guo Jianchun. Construction and Identification of

Full-length cDNA Library of Halophytes Sesuvium portulacastrumL. under Salt-

stress. Genomics and Applied Biology, 2010, 29(1):155-159. (in Chinese)

会议文章

Shanqing Zheng, Huairong Luo* (2011). Chlorogenic Acid Extends the Lifespan of

Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway. BeiJing, The 2ST C.

elegans meeting china. November 18-20, 2011.

Shanqing Zheng, Jeff Boudreau, Ian Chin-Sang* (2018). Activation of insulin signaling

causes Q cell divisions in Caenorhabditis elegans L1 arrest. Upstate New York C.

elegans Meeting. SUNY Upstate Medical University, Syracuse, NY. March 24th 2018

Syracuse University, Syracuse, NY

Shanqing Zheng, Jeff Boudreau, Ian Chin-Sang* (2018). DAF-18/PTEN and AMPK

inhibit PP2A and MPK-1 to block Q cell divisions in C. elegans L1 arrest. C. elegans

Satellite Meeting March 18th 2018 Mont Tremblant, PQ

Shanqing Zheng, Jeff Boudreau, Ian Chin-Sang*(2018). Activation of insulin signaling

induces cell divisions in C. elegans L1 arrest. C. elegans development, cell biology and

gene expression. 13 – 17 June 2018 | Barcelona, Spain.

基金参与情况

1. Canadian Institutes of Health Research (CIHR). The Role of Eph and Insulin

Receptor Tyrosine Kinase Signaling in C. elegans Neurodevelopment. Operating Grant.

参与人。

2. Natural Sciences and Engineering Research Council of Canada (NSERC):

Identification and characterization of genes involved in morphogenesis. Discovery Grant.

参与人。